Find out all about the supplement that supports muscle function –

You work out for real, in search of the dreamed defined body – hello, hello, summer project! Great, exercising, whether aerobic or anaerobic, is the way to stay in good shape.

But, to improve conditioning and resistance and still protect bones and joints from possible injuries, it is important to take care of the health and strengthening of the muscles.

“The human body works in a dynamic balance, that is, every day it undergoes muscle synthesis and degradation reactions, and this is a natural process. Specifically during physical activity, the body undergoes a series of metabolic changes and, among them, catabolism takes place, that is, the breakdown of muscle protein into amino acids, a process necessary to supply energy during exercise”, explains Fernanda Leme, nutritionist at consultancy Equilibrium Saúde e Nutrição.

That is, with each push-up, sit-up or squat, your muscle fibers undergo an expected damage, and it is through recovery that they reconstitute themselves. In this reaction, leucine, an amino acid present in foods that are a source of protein, plays an important role, as it activates protein synthesis, promotes muscle gain and increased strength.

To preserve lean mass

And if the goal is to prevent the loss of muscle mass and gain more strength and endurance – who doesn’t? The good news is the discovery of beta-hydroxy-beta-methylbutyric acid (HMB), a substance produced by the body via leucine metabolization, or ingested in source supplements, which performs various functions in the body. “With regard to the reduction of muscle damage, it is observed that HMB alters protein turnover, that is, it changes the balance between protein synthesis and degradation. What does that mean? That HMB is able to reduce the breakdown of proteins and, consequently, generate a positive turnover, with greater maintenance of lean mass”, says Fernanda.

Extra dose of HMB

Under normal health conditions, HMB is a metabolite produced by the body, but only 5% of the body’s leucine is converted into HMB (which corresponds to 0.2 to 0.4 grams of HMB per day), an insufficient amount to help muscle function.

This is where supplementation is gaining relevance, by offering benefits such as increase of protein synthesis and, consequently, muscular hypertrophy, reduce protein degradation in the muscles after the practice of intense physical exercises, collaborating with their recovery, and increase muscle strength and functionality.

According to the nutritionist, the consumption of HMB is indicated for both audiences. “Its performance in the protection of lean mass helps both those who intend to increase their muscle volume and those who seek to preserve lean mass – an important factor especially from the age of 50, when the loss of lean mass is accentuated. In women, with the hormonal change resulting from menopause, this difficulty can be even greater. The decrease in the amount of lean mass can lead to sarcopenia, which is the loss of muscle volume and strength, and compromise the quality of life.”

For those looking to support muscle function, Vitasay Muscle is a good choice. Thanks to the HMB present in the formulation, the supplement helps to increase muscle strength and endurance and prevent the loss of lean mass and also contributes to the reduction of muscle damage.

The HMB supplement can be consumed by anyone who wish attenuate protein catabolism. However, its use is indicated, mainly, for athletes and people who practice physical exercises and look for improve muscle gain and performance; people with low leucine intake who wish maintain muscle mass at normal levels and the 50+ public, who seek to inhibit muscle loss, a more pronounced process in this age group.

Bibliographic references:

Alvares TS, Meirelles CM. Effects of b-hydroxy-b-methylbutyrate supplementation on strength and hypertrophy. Nutrition Magazine. 2008, v. 21, no. 1, p. 49-61. . Available on: Epub 02 Apr 2008. ISSN 1678-9865. https://doi.org/10.1590/S1415-52732008000100006.

Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-betamethylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr. 2009 Jan-Feb;33(1):71-82. doi: 10.1177/0148607108322403. PMID: 19164608.

Borack MS, Volpi E. Efficacy and safety of leucine supplementation in the elderly. J Nutri. 2016 Dec;146(12):2625S-2629S. doi: 10.3945/jn.116.230771. Epub 2016 Nov 9. PMID: 27934654; PMCID: PMC5118760.

Durkalec-Michalski K, Jeszka J, Podgórski T. The effect of a 12-week beta-hydroxy-beta-methylbutyrate (HMB) supplementation on highly-trained combat sports athletes: a randomized, double-blind, placebocontrolled crossover study. Nutrients. 2017 Jul 14;9(7):753. doi: 10.3390/nu9070753. PMID: 28708126; PMCID: PMC5537867.

Gepner Y, Varanoske AN, Boffey D, Hoffman JR. Benefits of β-hydroxy-β-methylbutyrate supplementation in trained and untrained individuals. Res Sports Med. 2019 Apr-Jun;27(2):204-218. doi: 10.1080/15438627.2018.1533470. Epub 2018 Oct 22. PMID: 30348016.

Guedes JM, Peluzio MDCG, Rathmacher JA, Leal TF, Junior MAC, de Carvalho DM, de Oliveira LL, Natali AJ. βhydroxy-β-methylbutyrate supplementation benefits the effects of resistance training on body fat reduction via increased irisin expression in white adipose tissue. Biol Sport. 2021 Mar;38(1):113-121. doi: 10.5114/biolsport.2020.97671. Epub 2020 Aug 21. PMID: 33795920; PMCID: PMC7996383.

Holeček M. Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle wasting conditions. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):529-541. doi: 10.1002/jcsm.12208. Epub 2017 May 10. PMID: 28493406; PMCID: PMC5566641.

Kaczka P, Michalczyk MM, Jastrząb R, Gawelczyk M, Kubicka K. Mechanism of action and the effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation on different types of physical performance – a systematic review. J Hum Kinet. 2019 Aug 21;68:211-222. doi: 10.2478/hukin-2019-0070. PMID: 31531146; PMCID: PMC6724588.

Kuriyan R, Lokesh DP, Selvam S, Jayakumar J, Philip MG, Shreeram S, Kurpad AV. The relationship of endogenous plasma concentrations of β-Hydroxy β-Methyl Butyrate (HMB) to age and total appendicular lean mass in humans. Exp Gerontol. 2016 Aug;81:13-8. doi: 10.1016/j.exger.2016.04.013. Epub 2016 Apr 20. PMID: 27108182.

Lin Z, Zhao Y, Chen Q. Effects of oral administration of β-hydroxy β-methylbutyrate on lean body mass in older adults: a systematic review and meta-analysis. Eur Geriatr Med. 2021 Apr;12(2):239-251. doi: 10.1007/s41999-020-00409-9. Epub 2020 Oct 8. PMID: 33034021.

Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB). The Journal of Nutritional Biochemistry, v. 8, Issue 6, 1997, p. 300-311. ISSN 0955-2863. Available in: https://doi.org/10.1016/S0955-2863(97)00048-X.

Oktaviana J, Zanker J, Vogrin S, Duque G. The effect of β-hydroxy-β-methylbutyrate (HMB) on sarcopenia and functional frailty in older persons: a systematic review. J Nutr Health Aging. 2019;23(2):145-150. doi: 10.1007/s12603-018-1153-y. PMID: 30697623.

Pereira IFS, Spyrides MHC, Andrade LMB. Nutritional status of elderly people in Brazil: a multilevel approach. Public Health Notebooks . 2016, v. 32, no. 5 , e00178814. Available on: Epub 03 Jun 2016. ISSN 1678-4464. https://doi.org/10.1590/0102-311X00178814.

Portal S, Eliakim A, Nemet D, Halevy O, Zadik Z. Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices. J Pediatr Endocrinol Metab. 2010 Jul;23(7):641-50. doi: 10.1515/jpem.2010.23.7.641. PMID: 20857835.

Rathmacher JA, Pitchford LM, Khoo P, Angus H, Lang J, Lowry K, Ruby C, Krajek AC, Fuller JC, Sharp RL. Longterm effects of calcium β-hydroxy-β-methylbutyrate and vitamin D3 supplementation on muscular function in older adults with and without resistance training: a randomized, double-blind, controlled study. J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2089-2097. doi:10.1093/gerona/glaa218. PMID: 32857128; PMCID: PMC7566440.

Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor L, Wilborn C, Kalman DS, Stout JR, Hoffman JR, Ziegenfuss TN, Lopez HL, Kreider RB, Smith-Ryan AE, Antonio J. International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB). J Int Soc Sports Nutr. 2013 Feb 2;10(1):6. doi: 10.1186/1550-2783-10-6. PMID: 23374455; PMCID: PMC3568064.