Haloperidol: what is it and what is it used for?

Haloperidol is an antipsychotic or neuroleptic drug. Due to its chemical structure, it is included in the group of butyrophenones. It was discovered in 1958 by Paul Janssen. It belongs to the typical antipsychotics. Therefore, It is useful in the treatment of the positive symptoms of schizophrenia. Some of these are, for example: hallucinations, delusions or agitation.

It is a depressant agent of the central nervous system with a sedative effect.. Thus, it causes powerful motor sedation. This effect is used to combat states of agitation and aggressiveness.

What is haloperidol used for?

Haloperidol has many different indications in its technical specifications. It can be used on both adults and children. Basically, It is used as an antipsychotic in the treatment of schizophrenia and also in other psychotic states and agitation..

In adults, over 18 years of agehaloperidol is indicated for the treatment of:

Schizophrenia.Confusion syndrome that does not respond to non-drug therapies.Manic episodes associated with bipolar disorder. Psychomotor agitation associated with psychotic disorders. Aggression and psychotic symptoms in patients with Alzheimer’s dementia and vascular dementia.Tic disorders that do not respond to other types of treatments; including Gilles de la Tourette syndrome. Huntington’s chorea that does not respond to other treatments.

In pediatric patients it is used as long as other treatments cannot be used.; either because they do not respond to them or they are not tolerated. In these cases, haloperidol is indicated in:

Schizophrenia in adolescents aged 13 to 17 years. Aggression in children and adolescents aged 6 to 17 years with autism or developmental disorders. Tic disorders, including Gilles de la Tourette syndrome, in children and adolescents aged 10 to 17 years.

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Besides, Haloperidol is being studied for the prevention of delirium. Low doses of this drug appear to be useful in reducing the incidence of delirium in high-risk patients; as well as in patients who are going to undergo surgery.

Haloperidol is also used to prevent nausea and vomiting. It is useful in nausea and vomiting after surgery and also in those associated with chemotherapy. Various studies ensure its effectiveness and safety for this use.

Mechanism of action

Haloperidol is a potent dopamine receptor antagonist.. It works by non-selectively blocking central D2 receptors. It also has low antagonistic activity on alpha-1 adrenergic receptors.

By blocking the dopamine pathway, it reduces excess dopamine in the brain. So, Haloperidol suppresses delusions and hallucinations. It also produces a certain psychomotor sedation, useful in some of its indications.

Side effects

Haloperidol, like almost all psychotropic drugs, has a series of unwanted effects. These are usually also related to the mechanism of action. In fact, most adverse reactions to haloperidol are due to blockade of dopamine in other systems. The most common side effects of haloperidol are:

Extrapyramidal disorder.Insomnia.Agitation.Hyperkinesia.Headache.

Other adverse reactions Less common but which can also appear are:

Psychotic disorder.Depression.Weight gain. Tremor. Hypertonia. Orthostatic hypotension.Dystonia.Drowsiness.Urinary retention.Erectile dysfunction.Skin rash.Nausea and vomiting.Visual impairment.

Its use with other antipsychotics is not recommended. This is because it can increase the intensity of adverse reactions. Likewise, extrapyramidal effects can be enhanced.

A serious adverse reaction that can occur is neuroleptic malignant syndrome.. It is not very common, but it is advisable to know about it to be able to detect it in time. It usually occurs at the beginning of treatment. It causes muscle stiffness, high fever, arrhythmia, etc. Therefore, It is important to follow the doctor’s instructions. He is in charge of controlling the treatment, as well as assessing its effectiveness and possible risks.

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Treatment should be started with a low dose. Afterwards, this can be increased depending on the patient’s response and needs, periodically evaluating the benefit-cost balance of the treatment. Furthermore, to avoid adverse effects, the dose should always be the minimum effective.

Special care must be taken when used in elderly patients, as well as in children.. In these cases, the dose must be adjusted. And, in addition, we must monitor the possible adverse effects that may appear.