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Statins are cholesterol-lowering drugs that can cause side effects in the form of muscle conditions (myopathies) in about 10% of all patients.
These disorders They can manifest as muscle aches, cramps, muscle stiffness, or muscle weakness. In the worst and rare case, the muscle can break down under the action of cholesterol-lowering drugs, in these cases we speak of rhabdomyolysis, which can lead to acute kidney failure and be fatal.
Coenzyme Q10 could counteract the effect of statins
Coenzyme Q10 could be used preventively or even therapeutically for these ailments. It is a substance similar to vitamins, which the body produces on its own and which it is involved in the production of energy in cells, but it also has an antioxidant and anti-inflammatory effect.
A deficiency of coenzyme Q10 can not only accelerate the aging process, but also It can manifest itself in muscular, cardiac and neurological problems.
The problem is that the endogenous production of Q10 is affected by the consumption of statins. a dose of Atorvastatin 80 mg daily could halve the level of coenzyme Q10, from 1.26 to 0.67 µg / ml in the blood.
Other statins, such as simvastatin and pravastatin, in doses of 20 mg, can reduce the level of coenzyme Q10 by 40%.
In patients with a low level of coenzyme Q10 in the muscles, reduced mitochondrial function may be observed in studies. Decreased mitochondrial function means less energy for every cell in the body. It involves tiredness and weak muscles.
However, there are also studies that could not observe changes in Q10 levels in muscle biopsies even after 6 months of simvastatin use (20 mg daily). Hence it is said that statins They “can” cause discomfort and muscle damage, but they don’t always.
This is how statins reduce coenzyme Q10 levels
Statins can lead to coenzyme Q10 deficiency by at least two mechanisms:
statins prevent the formation of so-called mevalonic acid, which in turn would be necessary for the production of coenzyme Q10 in the body. In this way, statins reduce the level of coenzyme Q10, both in serum and in muscle tissue.Coenzyme Q10 binds to LDL cholesterol in the serum. If statins lower the LDL cholesterol level, this naturally also automatically leads to a lowering of the Q10 level.
Coenzyme Q10 improves statin-related muscle discomfort
A small increase in the concentration of coenzyme Q10 speeds up energy production and its effect can often be felt immediately.
In a study by Stony Brook University in New York, published in the American Journal of Cardiologyparticipants received 100 mg of coenzyme Q10 or 400 IU of vitamin E. After 30 days, pain intensity in the Q10 group had decreased by 40%.
The researchers concluded that coenzyme Q10 supplementation should accompany statin therapy, especially since it could prevent discontinuation of treatment due to side effects.
In a review of studies published in the Journal of the American Heart Association The beneficial effect of Q10 was confirmed, which was shown to be effective in reducing muscle damage caused by statins in many cases.
In some studies of Q10, no effect of Q10 intake could be determined. However, very low amounts of Q10 were often used in these studies (only 100 – 120 mg), so this underdosing could be one of the reasons for the lack of benefits.
Coenzyme Q10 may also reduce the risk of arteriosclerosis
Coenzyme Q10 may also be helpful in not only mitigating the side effects of cholesterol-lowering medications, but also directly reduces cardiovascular risk.
As explained above, coenzyme Q10 prevents the oxidation of LDL cholesterol to which it binds in the blood. It is precisely the oxidized LDL cholesterol that is very dangerous, since it can favor the development of arteriosclerosis.
Take Q10 at the same time as statins
Most experts agree that you should recommend taking coenzyme Q10 along with statin therapy. Competitive athletes could also benefit.
It is true that in some cases Q10 does not produce positive effects, but potential benefits predominate, so coenzyme Q10 can be tried in any case, especially since there are no known harmful side effects of Q10.
The recommended dose for the prevention of statin-related myopathy is at least 200 mg of coenzyme Q10.
On the other hand, it can be an interesting supplement for the elderly because the endogenous production of Q10 decreases over the years.
Scientific references:
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